Pharmacodynamic activity of ertapenem versus genotypically characterized extended-spectrum b-lactamase (ESBL)-, KPC- or NDM-producing Escherichia coli with reduced susceptibility or resistance to ertapenem using an in vitro model
نویسندگان
چکیده
Methods: Fifteen extended-spectrum b-lactamaseor carbapenemase-producing E. coli were studied. The in vitro pharmacodynamic model was inoculated with 1×10 cfu/mL and ertapenem was dosed once daily at 0 and 24 h to simulate free ( f ) Cmax and t12 obtained after either 1 g or 2 g intravenous once-daily doses in healthy volunteers (1 g: f Cmax 15 mg/L, t12 4 h). Sampling was performed over 48 h to assess viable growth and resistance selection.
منابع مشابه
Comparison of ertapenem non-susceptibility with 2-mercaptopropionic acid phenotypic tests in predicting NDM-1 and IMP-1 production in clinical isolates of Escherichia coli
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